IS (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. IS stands for Inter Sexuality.<br /><br />This manga deals with very serious issues concerning intersexual people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are - It's all there in a form of manga.<br /><br />The series is consisted of cases, each dealing with different people - although some cases are much longer and more dramatic than others.